Fladrafinil Review: 7 Big Benefits Of CRL-40, 941

Nootropics are sometimes called cognitive enhancers or smart drugs.

They are used by those who are hoping to improve their memory, to increase their mental alertness, and concentration.

There are many different types of nootropics available today, and they have the potential to provide people with some impressive benefits.

Let’s get a closer look at Fladrafinil to see whether it might be a nootropic you want to try.

What Is Fladrafinil?

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Otherwise known as CRL-40,941, Fladrafinil is a ‘wakefulness promoting’ research chemical that has numerous benefits.1

This smart drug has actually been around for decades. It was first created in the 1970s after receiving a patent in France.

While these pills don’t increase a person’s intelligence, they can help with memory and concentration.2

For this reason, Fladrafinil was popular with academics and others who wanted to improve their brain function.

You will find that it is also a eugeroic and like Modafinil, it helps to promote wakefulness.

Fladrafinil Benefits

To start, the benefits of Fladrafinil include:

  1. Improved energy
  2. Enhanced wakefulness
  3. Increased sense of calm
  4. Increased mental alertness
  5. Increased productivity
  6. Enhanced concentration and focus
  7. Lowered aggression

You can get the same sorts of benefits from Modafinil, which is considered to be one of the best cognitive enhancers in the world.3

The thing that separated Fladrafinil is that it is said to improve energy even more.

One of the interesting things about Fladrafinil that sets it apart from some of the other options like Adrafinil and Modafinil is that it has an anti-aggressive effect on animals.

This can help to keep someone calmer and lower their levels of aggression, all while providing the other types of benefits that are expected from these nootropics.

Let’s get a closer look at some of those benefits.

A benefit of Fladrafinil is an increase in mental alertness.

You may find that it provides you with a more awake alert feeling similar to what you would get with a stimulant without all of the negative effects associated with stimulants.

You can stay more awake, alert, and productive when you take this drug. Many use it to focus and to help prevent daytime sleepiness.

As this is a nootropic, it will also provide you with increased concentration and focus.

This means that not only will you feel more awake, but you will end up being more productive in most cases.

It may allow you to push away distractions and focus on the tasks before you.

Due to these benefits, Fladrafinil and other nootropics are popular with those who are engaged in many types of mental activities.

It can help with work, studying, and more.

Many who have taken Fladrafinil also benefit from improved memory and recall.

It is believed that the product can help people to form new memories and to retrieve old ones.

This makes the product beneficial to just about everyone, but it could be even more beneficial to seniors.

A lot of older individuals have trouble when it comes to their memory.

Because it is believed that Fladrafinil can help people of all ages, it could help those who have declining cognitive capabilities.

Of course, as with many areas involving this drug, there still needs to be a lot of research done.

Here’s one of the benefits of Fladrafinil that doesn’t get as much attention as it should.

Because it inhibits the breakdown of dopamine, it often means that those who take it have improved moods and reduced stress levels.

It stimulates the release of serotonin, as well, which increases feelings of happiness and well-being.

Having added serotonin often means better sleep, as well. Getting better sleep can help with many areas of your life and health.

The increased serotonin and higher levels of dopamine that stay in the body could also contribute to the reduced aggression often associated with the drug discussed above.

Most will agree that Fladrafinil could be more powerful than similar options like Adrafinil and Modafinil, and even Lauflumide.4

The only thing that is potentially holding it back, though is the fact that the research into the drug is still minimal.

While some of the benefits have been studied and corroborated, there is still a lot of anecdotal evidence when it comes to the effectiveness of Fladrafinil.

Many people feel that it works well and that the side effects are virtually nonexistent.

How Does Fladrafinil Work?

Fladrafinil, when it is ingested, will be metabolized by the body into Modafinil, which will then affect your central nervous system.

However, a lot of research is still being done with Fladrafinil despite being created more than 40 years ago.

More research is needed to determine the exact mechanisms of action.

There was a study done in 2010 that looked into the effects of Fladrafinil as a cognitive enhancer.

In the study, adults were given 40 mg of the drug for more than a week and were asked to complete a monotonous activity.

The researchers found that the nootropic was able to improve a person’s cognitive ability and performance when they were completing the tasks.

This study also noted the lower aggression and the reduction in feelings of sedation and fatigue in those who took it when compared with those who were taking a placebo.

The researchers believed that it could help those who needed to improve their focus and memory.

Side Effects of Fladrafinil

You don’t want to just take a supplement without knowing how it can affect you both positively and negatively.

It’s always important to think about the side effects.

Since there has not been as much research into Fladrafinil, less is known about the potential side effects.

Thus far, there aren’t any major side effects that have been reported, but there is some anecdotal evidence of issues that some people have had.

Most of the side effects discussed tend to be mild and they occur with higher doses.

Some people complain of headaches and nausea.

Others have said that they have insomnia.

Since the nootropic can cause wakefulness and provide more energy, it’s normal that there could be more difficulty sleeping depending on the time of day it is taken.

For this reason, you might want to make sure you take your dose earlier in the day rather than in the afternoon.

When you start taking Fladrafinil, you should take note of how you feel.

If there are any issues you notice, make sure that you talk with a doctor and potentially stop taking the nootropic until you find the source of the problem.

Does Fladrafinil Really Work?

No one wants to spend money on supplements that don’t work.

They don’t want to keep putting substances into their body if they are not getting the results they want.

This is normal.

You want to know that it works before you buy hundreds of dollars in supplements.

Fortunately, you will find that for most people, Fladrafinil can work quite well.

Once they start taking it and stick to a schedule, it can help to provide the types of benefits mentioned above, at least according to them.

A customer who bought some of the Fladrafinil from a popular online retailer said:

“Worked well. Better than Modafinil actually with a calming effect (anti-aggressive). Would definitely buy again just not available as often as I need it.”
– MateoWampleaza

From the same site, Morgan Wiggs said:

“Works well and no edgy feeling from it and it definitely helps life my brain fog and exhaustion. I’d buy again for sure.”

On Reddit, there are similar positive stories about Fladrafinil.

“I love Fladrafinil! Too bad that the vendor I prefer is moving on to something new, but yeah. I have to say, of all I’ve tried, Fladrafinil is the absolute best for me personally. Hydrafinil, which I’ve switched to recently, is somewhat close. Very stimulating which I thought was interesting. It’s probably the closest to any I’ve tried. That includes the Hydrafinil, Adrafinil, Prescription Modafinil through my doctor, and fluoromodafinil. There are 2 flavors of fluoromodafinil from what I’ve read. 2-bis-(4-fluoro)-modafinil and a newer soon-to-be flavor. The former I’ve tried, and it’s not that effective for me personally, but then again, this was through a supplier that I previously got Fladrafinil from and thought Fladrafinil was lame as well (until I tried a different source).”
– RMCFar11, Reddit

To get some additional information from people who have used these products, you can find some YouTube channels with videos discussing Fladrafinil.

One that does a great job of covering the topic is Fladrafinil Nootropic Smart Drug Review from RealJoshTV.

Here’s what he had to say:

How to Use Fladrafinil

When you are taking Fladrafinil, you will want to stay between 40 mg and 200 mg per day.

If you take more than this, there is a greater potential for side effects because of the long half-life, which is between 14 and 16 hours.

The majority of people tend to stick to between 40 and 80 mg per day.

Typically, you can find either powdered Fladrafinil or tablets.

The tablets tend to be a nice and easy way to get what you need. It also makes it easier to take along with you in case you are traveling.

You will still want to keep up with your regimen after all. The amount in the tablets can vary, of course.

If you are taking the 40 mg tablets, then you will want to take between two and five of these pills a day depending on the dosage that you want to hit.

If you are just starting to use these nootropics, you will find that it tends to be a good idea to start with the lower dosage just to see how you feel.

You can then move it up to the higher daily dosages if you wish.

Although the side effects tend to be quite rare, and most people will not have any trouble when it comes to taking the nootropic, pay attention to how you feel.

If you notice any unpleasant or problematic side effects, stop taking it and consult a doctor just to be on the safe side.

Where Can You Buy Fladrafinil?

You will be able to buy your Fladrafinil online easily through Pure Rawz, where you can find several variations.

You can choose from the 27-count or 54-count of 40 mg tablets, click here to see their page on that.

You can also choose their powder version, which they sell a 1 gram bag for just over $30.

Click Here to see their page on the powder version of Fladrafinil.

Buying the larger size is a bit cheaper than choosing the smaller option, so it’s a good choice if you are buying in bulk and want to save.

One of the best ways to save even more money is by ordering more than $100 worth of products from the store.

When you do, you can get free shipping. The site provides secure checkout and high-quality products.

Additionally, there is a 100% satisfaction guarantee.

Buying online is easy, and it will provide you with an easy way to get the nootropics and other supplements right to your door.

It’s easy to order, and the delivery tends to be fast.

Always make sure you are ordering from a trustworthy source, though.

Remember, these pills are 40 mg each and they come in packs of either 27 or 54.

Calculate how many of these packs you will need to buy each month based on your dosage.

For example, if you are just taking two pills a day, then the pack of 27 will last for 13 days with one pill left over.

Even if you are only taking one of the 40 mg pills per day, you will still need more than one pack, so buy accordingly.

It should be stored at room temperature and kept out of light.

This will ensure that it lasts longer.


Do you have trouble concentrating and getting through the day?

Have you found that you just can’t keep your focus to get through tasks that should be simple?

Maybe you just feel as though you are sleepy through most of the day, which is slowing you down.

It could be time to consider trying a nootropic like Fladrafinil.

Although there is still research being done, it has shown a lot of promise, and many people swear by it.

As long as you stick to the normal dosage, as mentioned above, and pay attention to how you feel, it could be just what your brain needs.

Fladrafinil could be the perfect cognitive enhancer for you.


  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 13316557, Fladrafinil. Accessed May 19, 2022. (source)
  2. Dowling G, Kavanagh PV, Talbot B, et al. Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog. Drug Test Anal. 2017;9(3):518-528. doi:10.1002/dta.2142 (source)
  3. Napoletano F, Schifano F, Corkery JM, et al. The Psychonauts’ World of Cognitive Enhancers. Front Psychiatry. 2020;11:546796. Published 2020 Sep 11. doi:10.3389/fpsyt.2020.546796 (source)
  4. Luca G, Bandarabadi M, Konofal E, et al. Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound. Front Neurosci. 2018;12:519. Published 2018 Aug 15. doi:10.3389/fnins.2018.00519 (source)

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Paul Musumba
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Fladrafinil is a popular nootropic, but does it really work? Our review covers the benefits, how to take it, side effects, where to buy it, and more.

By Paul Musumba

Paul Musumba has been an organic chemistry instructor for CHAD Phila since December of 2017. Prior to his stint at CHAD, he was a chemistry teacher at Delaware Valley Charter High School in Philadelphia. He received a B.S. in Biology and Organic Chemistry from Drexel University in 2010, and a masters degree in Chemistry and Computer Science with Teaching, Organic and computational Chemistry from Temple University in 2016. You can read more about Paul's experience and publications on his LinkedIn profile here:

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