Some peptides occur naturally in the body. After all, they are just amino acid chains.
However, other peptides have been created in the lab, and these can produce some rather impressive results when used by humans.
One of the best and most interesting options to consider is GHRP-6.
Below, you’ll learn more about this peptide, what it can do, how to take it, and more.
Table of Contents
What Is GHRP-6?
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GHRP’s are a class of synthetic oligopeptides which are said to help stimulate growth hormone release.1
GHRP-6 is a growth hormone-releasing peptide that contains a sequence of 28 amino acids, and it’s believed that it also contains unnatural D-amino acids.2
The unique structure is what makes GHRP-6 special.
This has been available for more than a decade, and there has been a range of studies on it.
The peptide is meant to stimulate the release of growth hormone in the body, which can be useful for those who are looking for anti-aging benefits, as well as for athletes and bodybuilders.3
You will find many potential benefits when choosing to take GHRP-6.
Thanks to the properties of GHRP-6, it is believed to be a good option to help treat a range of different conditions including growth hormone deficiency, obesity, eating disorders, and cachexia.4
It could also provide benefits for the hearts and the cells of different parts of the body, according to a 2017 study discussed below.
There are plenty of other benefits users can reap when they choose to take GHRP-6.
Let’s get a closer look at these.
Of course, the first reason that someone will want to use this peptide is that it works so well to ramp up the growth hormone in the body.5
Taking the GHPR-6 can help you to gain weight and strength relatively quickly.6
However, you will find that it offers some other benefits, too.
It can help with weight loss, despite the fact that you may have an increased appetite.
Another study indicated that GHRP-6 can help stimulate sleep, growth hormone, ACTH, and cortisol release in men.7
This can help increase muscle size and mass, as muscle is repaired during periods of deep sleep.
The more muscle you put on the better it will be for burning fat and boosting your metabolism.
You can experience increased energy levels, as well as improved endurance and stamina.
Because of the improved strength, added muscles, and energy, you might even find that your libido is stronger.
When you feel better and you start to look better, your confidence will grow.
This often helps to get you in the mood.
You will also find some surprising benefits that have become associated with GHRP-2.
This includes having healthier hair and a boosted immune system.
Another study noted that GHRP-6 can help enhance the healing process, as well as improve the esthetic outcome of wounds.8
You can feel better by taking these peptides, and it can even improve your outlook on life given the other benefits mentioned above.
With all of the benefits that come from GHRP-6, it is easy to see why so many people have started to use this peptide.
How Does GHRP-6 Work?
In the gut, there is a naturally occurring peptide known as ghrelin, and it can trigger the release of growth hormone when it is activated.
The GHRP-6 that you take can activate the ghrelin by binding to the ghrelin receptors.
This then sends signals to the anterior pituitary gland, which then tells the body it’s time to release more growth hormone.
However, the GHRP-6 doesn’t just help to release more growth hormone. It also acts as an inhibitor of somatostatin.
When the somatostatin decreases, the signaling pathway for the regulation of growth hormone levels drops.
This allows for an even greater increase of growth hormone in the blood.
Because there is a higher amount of growth hormone in the body, it means there is a greater release of insulin growth factor-1 from the liver.
IGF-1 is an anabolic hormone that is important for the growth and development of the body and muscles.
In studies, GHRPs have been found to provide results that help to corroborate the potential benefits mentioned above.
A 2017 study published in Clinical Medicine Insights: Cardiology found that there has been mounting evidence showing that GHRP-6 can provide certain cytoprotective abilities including the reduction of cellular death, reduced inflammation, and improved antioxidant defenses.9
Side Effects of GHRP-6
Although the supplement has some amazing benefits, it’s only natural that you want to make sure you have a good handle on potential side effects.
While side effects do tend to be rare, they can still occur.
It’s important to know what they are in case you encounter them.
One side effect that some people feel when they take GHRP-6 is some pain in the joints.
This is a temporary side effect that goes away in a very short period.
It occurs because the body is getting accustomed to the added cortisol that occurs when using GHRP-6.
Another side effect that some people experience when taking the peptide is a feeling of dizziness or lightheadedness.
This might also present with a feeling of a head rush and having pins and needles in the hands and feet.
You might also notice that you have more headaches than usual when you are taking the peptide.
This is because it could cause your blood sugar levels to be lower than normal.
A healthy snack can often make those headaches go away.
However, you will want to keep an eye on your appetite.
Increased appetite is one of the other things you may have to deal with when you take GHRP-6.
This is common with GHRP-2, as well, but it is more prominent and more powerful with GHRP-6.
This tends to be a problem that is relatively easy to solve, as long as you have prepared for it.
Make sure not to overeat and have only healthy, low-calorie snacks on hand when you do start to feel hunger pangs.
While side effects can and do happen with GHRP-6, they tend to be rare and manageable for the most part.
Most people shouldn’t have any major issues when they are using this peptide, as long as they are following basic guidelines on usage.
Don’t use too much and don’t stay on a cycle for too long.
If there are other effects that you feel or experience when you are taking the supplement, quit taking it and speak with a medical professional.
It’s always better to be safe rather than sorry.
Does GHRP-6 Really Work?
When you are spending money on supplements, you want to make sure they are going to work.
No one likes the idea of spending hundreds of dollars on products that don’t produce any results.
Fortunately, you will find that GHRP-6 doesn’t have this problem.
This peptide is the real deal and when it is taken properly, it can produce some impressive results.
To get a better idea of the types of experience you can have with the peptide, consider some of the YouTube channels dedicated to health and fitness that focus on them.
Elite Athlete has a video called GHRP-6 Explained Like Never Before, which takes a dive into this peptide and what it can offer.
Check it out below:
Other channels that have videos talking about the benefits and how to use the peptide include Big Tex Gym, Muscle Insider, House of Anabolics, and Peptide Knowledge.
Here’s a few of the more interesting and informative ones:
These are real people who have used the peptide.
Keep in mind that most of the information you will find will be from people who are using the GHRP-6 for bodybuilding.
While the other benefits can still occur, most people are interested in what the peptide can do for their muscle size.
How to Use GHRP-6
When you are taking GHRP-6, it should be done on an empty stomach.
Additionally, you will not want to consume any food for at least 15 to 20 minutes after the injection.
If you eat too soon after the injections, you will not get the maximum amount of GH injected.
When you receive the GHRP-6, it will come in a vial in a crystallized form. Before it can be used, it needs to be reconstituted.
You can do this using bacteriostatic water or sterile water.
Clean the water vial with an alcohol swab before you use a needle to remove any water. Do the same to the peptide vial.
Wait for about 30 seconds after wiping down the vial for the alcohol to dry.
For a 5 mg vial, you can use 1 ml of water, and for a 10 mg vial of GHRP-6, you can use 2 ml.
When you add water to the vial, don’t just squirt it into the peptide. Instead, you want to slowly drip the water down the side of the vial.
It needs to be a gentle addition, or it could ruin the peptides.
Once the water has been added, it should mix with the peptide and eventually become clear rather than cloudy.
As always, the peptides should be kept in the refrigerator, so they will last longer.
This is true both before and after they have been reconstituted.
When you are injecting GHRP-6, the average dose should be between 100 to 150 mcg per injection.
The dosing frequency will be one to four times per day depending on the effects that you are hoping to achieve.
Typically, those who are opting for lower doses between 100 and 200 mcg per day are looking for the antiaging benefits.
Those who have higher overall daily does will be looking to add muscle to their frames.
You need to be sure to inject the peptide properly.
The procedure will be essentially the same for all injectable peptides. The typical cycle for GHRP-6 is between 12 and 14 weeks.
You could have a cycle that lasts for up to 16 weeks, but you don’t want to continue using it without a break for any longer than this.
How long will it take before the peptide kicks in and starts to work?
Fortunately, it tends to happen quite quickly.
For most people, it will only take about 20 to 30 minutes before you start to feel those aforementioned hunger pangs.
You will want to make sure you control them at this time, or there is a good chance you could overeat.
Where Can You Buy GHRP-6?
You will find that the best place to buy your GHRP-6 and other peptides will be online.
The Internet makes it easy to find the supplements you need, and it’s possible to find some high-quality options, such as the GHRP-6 from Core Peptides.
They offer 5 mg vials for $20, making it the cheapest source for GHRP-6 available.
Additionally, if you buy more than $100 worth of products, the shipping will be free, which can help you to save some money.
They also offer GHRP-6 in combination with other effective peptides, such as CJC-1295 and GHRP-6 here.
The site provides you with secure checkout and a 100% satisfaction guarantee.
You will get a high-quality product that works well and that can be delivered right to your door.
You could buy enough for your cycle all at once, or you could buy them over the course of your cycle.
Regardless, you will want to make sure they stay refrigerated and that you are careful not to drop the vials or disturb them too much.
If you aren’t careful and the peptides are agitated, they might become useless.
As you can see, GHRP-6 has some great benefits, and it works well for its intended purposes.
Many users have had success getting stronger and building muscles while taking the peptide.
YouTubers, regular bodybuilders, and those who want to try to turn back the hands of time have all found that the peptide can work wonders.
That doesn’t mean that it’s without some potential side effects, but they tend to be minimal.
If you want to have these types of benefits, now is the perfect time to try this peptide.
Once you learn how to reconstitute it and inject yourself, it’s easy.
Take a cycle and see how you feel.
Argente J, García-Segura LM, Pozo J, Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res. 1996;46(4-5):155-159. doi:10.1159/000185015 (source)
- Berlanga-Acosta J, Abreu-Cruz A, Herrera DGB, et al. Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects. Clin Med Insights Cardiol. 2017;11:1179546817694558. Published 2017 Mar 2. doi:10.1177/1179546817694558 (source)
Lei T, Buchfelder M, Fahlbusch R, Adams EF. Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells. J Mol Endocrinol. 1995;14(1):135-138. doi:10.1677/jme.0.0140135 (source)
- Zheng Q, Qiu WC, Yan J, et al. Prokinetic effects of a ghrelin receptor agonist GHRP-6 in diabetic mice. World J Gastroenterol. 2008;14(30):4795-4799. doi:10.3748/wjg.14.4795 (source)
Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Façanha CF, Liberman B, Lengyel AM. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Clin Endocrinol (Oxf). 1997;46(3):295-300. doi:10.1046/j.1365-2265.1997.1270942.x (source)
Granado M, García-Cáceres C, Frago LM, Argente J, Chowen JA. The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status. Endocrinology. 2010;151(5):2008-2018. doi:10.1210/en.2009-1394 (source)
Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology. 1995;61(5):584-589. doi:10.1159/000126883 (source)
- Mendoza Marí Y, Fernández Mayola M, Aguilera Barreto A, et al. Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds. Plast Surg Int. 2016;2016:4361702. doi:10.1155/2016/4361702 (source)
- Mendoza-Mari, Yssel & Fernández Mayola, Maday & Vázquez-Blomquist, Dania & García Ojalvo, Ariana & Suárez-Alba, José & Guillen, Gerardo & Barreto, Ana & Bermúdez-Álvarez, Yilian & Ugarte, Dayana & Garcia del Barco, Diana & López-Mola, Ernesto & Selman-Hussein, Manuel & Berlanga-Acosta, Jorge. (2017). GHRP-6, a novel candidate for prevention and treatment of fibrotic disorders. Biotecnologia Aplicada. 34. 2501-2504. (source)