PT-141 Peptide Review: 8 Big Benefits For Men & Women

Peptides are strings of amino acids, many of which occur naturally in the body.

However, others are made in laboratories and can be taken for various health benefits.

Some of these, such as PT-141, can potentially provide a wide range of benefits for the sexual health of users.

Let’s learn more about the PT-141 peptide and see who might want to consider taking it.

What Is PT-141?

pt-141 peptide reviews and results

Note: Click Here to pick up PT-141 legally from our #1 source, Core Peptides.

PT-141 is the developmental code for bremelanotide, a peptide that was originally created to help with sunless tanning.

However, during the first testing phases of this peptide, it was discovered that it had a different effect on the body.

It caused sexual arousal.1

Given the fact that a lot of people today suffer from sexual dysfunction, this PT-141 was a happy but unexpected benefit.

It became a useful peptide hormone for both men and women, helping to improve their sexual function.

Benefits Of PT-141

Some of the more common benefits associated with using PT -141 include:

  1. Increased libido in both men and women
  2. Improved confidence and self-esteem
  3. Reduced stress
  4. Decreased signs of depression
  5. Increased mood
  6. Stimulates the immune system
  7. Potentially lower blood pressure
  8. Decreased fat storage

Let’s talk about each of these benefits in detail below:

Using the peptide has been found to be a good option for increasing libido in men while helping to increase the desire for intimacy in women.2

The rejuvenation of the sex drive and improved sexual function could help many couples who are having trouble in the bedroom.

Sexual dysfunction can be caused by any number of issues. In some cases, it might be psychological.

Some may have a fear of intimacy, or they might have anxiety or depression. It could be fear due to previous trauma.

The issues could also stem from certain medical conditions, prescription meds, drugs, alcohol, or physical issues.

PT-141 could help in many of these instances.

In addition to helping improve sexual performance in men and women, PT-141 can also help to improve a person’s confidence and self-esteem.

People feel better about who they are and are often more likely to take good care of themselves.

This, along with better sexual function, can help to reduce stress, lessen depression, and boost a person’s mood.

There is also evidence that it can help to stimulate the immune system.

It could help to improve bladder control, strengthen the pelvic floor muscles, and reduce the risk of heart attack and stroke.

The peptide may also help to lower blood pressure and burn calories and fat.

Given all of the benefits that PT-141 is supposed to provide, it is little wonder that more and more people are considering taking this peptide.

Of course, those who want to benefit from the peptides should understand how they work, along with potential side effects, how to properly use the peptides, and where to easily purchase PT-141.

We will cover all of these things under the section on clinical studies below.

PT-141 Clinical Studies

We came across several studies of PT-141, and the results were very surprising.

Study #1

In men that showed an inadequate response to Viagra, PT-141 was administered to health male volunteers.

The study, which was conducted in April of 2004, showed some promise.

The men were given a low dose of PT-141, and their erectile response showed statistically significant improvement in erectile function.3

Study #2

In a similar double-blind, placebo-controlled study conducted on men that were responsive to Viagra, a 7 mg dose of PT-141 was administered to health male subjects.

Not only was it well tolerated, but all of the men showed improved erectile function within 30 minutes of administration of the peptide.2

Study #3

In yet one more study, the use of PT-141 in combination with Sildenafil (the active ingredient in Viagra) was studied in 19 patients.4

Those patients were administered 25 mg of Sildenafil and 7.5 mg of PT-141 intranasally.

Of course, a control group were given an intranasal placebo spray and a placebo tablet to measure the differences between the 2 groups of men.

The results were staggering, to say the least…

Not only was the erectile response dramatically enhanced in the men in the treatment group, but the study showed that the combination was well tolerated and did not result in any new side effects or an enhancement of the usual side effects.

Study #4 (Women)

PT-141 was clinically studied on premenopausal women with sexual arousal disorder.

While the sample size of 18 women was small, the results were impressive to say the least.

Women reported significant increases in sexual desire, improved genital arousal, and significant improvement in their level of sexual arousal.5

Study #5 (Women)

Another study conducted on 327 premenopausal women in 2016.

In it, the patients in the treatment group received 0.75, 1.25 or 1.75 mg of PT-141.

The results of the study speak for themselves…

All of the women showed considerable improvement in satisfying sexual events on a monthly basis, an increase in female sexual function, and improvements in desire, arousal, and orgasm quality.6

How Does PT-141 Work?

PT-141 works differently than a lot of other types of supplements, which go through the vascular system.

Instead, this peptide bypasses the vascular system and works directly on the nervous system.

Other types of treatments that are often used for erectile dysfunction, for example, work through the blood system.7

While they may be able to provide the user with an erection, that’s all they can really do.

PT-141 differs from those vascular-dependent medications.

This provides people with the actual desire that is often missing from their sex lives.

Not only does it help to kindle that desire, but it also allows for better, stronger erections, and helps both men and women to get into the mood.

The fact that it works through the nervous system is one of the reasons that people are choosing peptides rather than other options.

They feel that it is a safer option than medications and supplements that go through the cardiovascular system.

This is often the case with those who may have heart conditions, but who still want to have a good, healthy sex life.

The below video by fitness trainer Ryan Ankrom does a fairly good job of explaining the sexual benefits of PT-141:

Side Effects of PT-141

Everyone wants to be safe when it comes to the supplements they are taking. Are there a lot of side effects with PT-141?

You will find that the side effects tend to be rare, and for most people, they will be mild.

Still, they could be more problematic for certain people, as everyone reacts differently to supplements and medication.

Some of the more common but mild side effects include slight nausea and vomiting, hot flashes, flushing, cough, stuffy nose, tiredness, headache, and dizziness.

In the case of those who are taking injections, there could be numbness, tingling, bleeding, or pain at the injection site.

One of the other things you have to keep in mind with this peptide is its original purpose.

This was supposed to help with sunless tanning. In some people, this can cause tanning around the face and breasts.

These effects could be permanent. This happens more often in users who have darker skin.

It is very rare, but it could happen.

More serious side effects could occur, but they are exceedingly rare.

This could include a slowed heartbeat, ongoing and/or severe nausea, and high blood pressure that causes severe headaches or blurred vision.

The heart rate and blood pressure should return to normal levels within 12 hours of taking the PT-141.

In those rare cases where it doesn’t, you will want to speak with a doctor.

Although there are potential side effects, you will be happy to note that they tend not to be major problems for most people who choose to take PT-141.

The one that seems to be the most common in reviews is nausea.

It can occur immediately, or several hours after taking the peptide.

Does PT-141 Really Work?

Not only do you want to know that what you are putting in your body is safe, but you also want to know whether it works or not.

No one wants to waste their time or money on things that just don’t work.

Fortunately, you will find that PT-141 has quite a few great reviews from people who have used it and who continue to use it.

They proclaim that it really does work and that it provides them with all of the purported benefits.

Lance Hitchings, a YouTuber with more than 32,000 subscribers did a video on PT-141.

He goes into detail about what the peptide is, how it works, and his personal experiences with it.

The comments section on the video provides more insight from people who have watched the video and who have taken PT-141.

It can provide you with a better idea of what you can expect.

Another YouTube channel, Live Like a Viking, discusses how the PT-141 works, as well, and gives you an inside perspective into what he and his wife experienced.

It includes some humorous anecdotes, especially when he realizes that the product works a lot better than he had initially thought.

Of course, it’s not just YouTubers that are taking and enjoying PT-141 either.

In 2020, beautiful actress Suzanne Somers of Three’s Company, She’s the Sheriff, and Step by Step fame said that even though she is in her 70s and her husband is in his 80s, they have sex just about daily.

One of their keys to sexual success, she says, has been PT-141.

With so many positive reviews, you can see why PT-141 is well worth trying.

When you are purchasing your peptides, be sure to check out some of the reviews on their website.

This can give you a better idea of what to expect from the products you buy.

How to Use PT-141

PT-141 can be administered in various ways.

One of the common ways it is provided is via a subcutaneous injection in fat deposits in the body.

There are other options, as well, including nasal sprays, oral medications, and creams.

How much of the PT-141 should you take at once?

Typically, a 2 mg dose via injection is going to be effective for both men and women, and it should be taken about an hour before planned intercourse for the best effects.

It will go to work on your brain to help increase sexual desire since it works on the nervous system.

One of the questions that people often have when they consider taking PT-141 is just how fast it goes to work and how long it can last.

The answers to these questions can vary.

Typically, most people will start to feel the benefits within about 60 minutes or so.

It’s a good idea to try to time taking the PT-141 correctly, but it will last for anywhere from 24 to 36 hours.

You have plenty of time once you take it, so don’t worry.

The half-life of PT-141 is between six and eight hours, but as mentioned, it can last for up to 36 hours.

You can use this peptide up to three times per week.

You will want to make sure that you spread out the doses, so you aren’t taking them for three days in a row, as it could still take some time to get out of your system.

A lot of people who take the peptide find that their libido is raised for a day or two after they take it.

This is why you don’t need to take it very often.

Something important to keep in mind when it comes to taking PT-141 is that people will react differently.

Some might feel the effects immediately. For others, it might take an hour or even several hours.

Some will have one or more of the side effects mentioned above.

When you are first taking the PT-141, you should make sure that you use some common sense.

You should take it on a day where you don’t have anything to do and nowhere to go for the next 24 hours or so.

This will give it time to work and to get out of your system.

Where Can You Buy PT-141?

The Internet is the best place to purchase PT-141, and you can find just what you need through Core Peptides here.

You will find a 10 mg bottle available through the site.

The product has been well-reviewed and the site offers a 100% satisfaction guarantee.

The site provides you with secure checkout, and you will even receive free shipping when you purchase orders totaling $100 or more.

Buying through the site will ensure a quality product is delivered right to your home.

Check out some of the other options available through the site, as well, to see if there are other options that interest you:

A 10 mg bottle is enough for five experiences, which could get you through a couple of weeks if you are taking it regularly.

You may find that it’s a better idea to buy a couple of bottles at the same time since you can get free shipping when you hit the $100 mark.

When you are purchasing any sort of supplement, you should always be sure to check for reviews from other customers.

Additionally, you don’t want to choose a low-quality version of PT-141.

Find a good supplier and manufacturer who can be trusted to provide high-quality supplements.


PT-141 really does work, and there are plenty of happy men and women who have experienced it who can attest.

Just make sure that it’s right for you and that you are using the proper doses.

You don’t want to use too much, especially when you first use it.

Consider starting with a smaller dose. Make sure you see how it affects you and whether you suffer from any side effects.

You can then go up to the standard dose mentioned above once you see how it works.

Take note of how you feel, and if you like the experience, consider buying more to have on hand.

This peptide, after all, has become popular for good reason.

If you have been lamenting your sex life lately, or if you just haven’t felt like you are in the mood as much, consider PT-141.

Of course, even if you are not dealing with erectile dysfunction or lack of interest in sex, you might still want to try it to see how it works and what it can do to improve your sex life even beyond what it is right now.


  1. Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003;994:96-102. doi:10.1111/j.1749-6632.2003.tb03167.x (source)
  2. Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res. 2004;16(1):51-59. doi:10.1038/sj.ijir.3901139 (source)
  3. Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16(2):135-142. doi:10.1038/sj.ijir.3901200 (source)
  4. Diamond LE, Earle DC, Garcia WD, Spana C. Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology. 2005;65(4):755-759. doi:10.1016/j.urology.2004.10.060 (source)
  5. Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J Sex Med. 2006;3(4):628-638. doi:10.1111/j.1743-6109.2006.00268.x (source)
  6. Clayton AH, Althof SE, Kingsberg S, et al. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Womens Health (Lond). 2016;12(3):325-337. doi:10.2217/whe-2016-0018 (source)
  7. Kim S, Cho MC, Cho SY, Chung H, Rajasekaran MR. Novel Emerging Therapies for Erectile Dysfunction. World J Mens Health. 2021;39(1):48-64. doi:10.5534/wjmh.200007 (source)

See Also 

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MOTS-C Review: 10 BIG Benefits Of This Peptide

HGH Fragment 176-191 Review

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TB-500 Peptide Review

Paul Musumba
PT-141 Peptide

PT-141 Peptide

4.6 out of 5 (83 Ratings)

PT-141 is a peptide that shows promise at helping men and women improve their sexual desire, but does it really work? Find out in our exclusive review.

By Paul Musumba

Paul Musumba has been an organic chemistry instructor for CHAD Phila since December of 2017. Prior to his stint at CHAD, he was a chemistry teacher at Delaware Valley Charter High School in Philadelphia. He received a B.S. in Biology and Organic Chemistry from Drexel University in 2010, and a masters degree in Chemistry and Computer Science with Teaching, Organic and computational Chemistry from Temple University in 2016. You can read more about Paul's experience and publications on his LinkedIn profile here:

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